Blar i forfatter "Neupane, Sudan Prasad"

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    • Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption 

      Bjørkhaug, Steinar Traae; Aanes, Håvard; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Malvik, Stine; Henriksen, Christine; Skar, Viggo Øystein; Medhus, Asle Wilhelm; Valeur, Jørgen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-20)
      Excessive alcohol intake can alter the gut microbiota, which may underlie the pathophysiology of alcohol-related diseases. We examined gut microbiota composition and functions in patients with alcohol overconsumption for >10 years, compared to a control group of patients with a history of no or low alcohol intake. Faecal microbiota composition was assessed by 16S rRNA sequencing. Gut microbiota ...

    • Cytokine concentrations are related to level of mental distress in inpatients not using anti-inflammatory drugs 

      Toft, Helge Prytz; Lien, Lars; Neupane, Sudan Prasad; Abebe, Dawit Shawel; Tilden, Terje; Wampold, Bruce E.; Bramness, Jørgen G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)
      <p><i>Objective - </i>Cross-sectional data show elevated levels of circulating cytokines in psychiatric patients. The literature is divided concerning anti-inflammatory drugs’ ability to relieve symptoms, questioning a causal link between inflammatory pathways and psychiatric conditions. We hypothesised that the development of circulating cytokine levels is related to mental distress, and that this ...

    • The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment 

      Toft, Helge Prytz; Neupane, Sudan Prasad; Bramness, Jørgen Gustav; Tilden, Terje; Wampold, Bruce E.; Lien, Lars (Journal article; Peer reviewed, 2018-04-10)
      <b>Background</b><br> Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol ...

    • High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders 

      Neupane, Sudan Prasad; Lien, Lars; Martinez, Priscilla; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Hestad, Knut; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-03)
      <p><i>Aims - </i>As major depression (MD) is often comorbid with alcohol‐use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)‐6, IL‐10, tumor necrosis factor (TNF), and interferon (IFN)‐γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels were also assessed. <p><i>Methods - </i>A ...

    • PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress 

      Toft, Helge Prytz; Bramness, Jørgen Gustav; Lien, Lars; Abebe, Dawit Shawel; Wampold, Bruce E.; Tilden, Terje; Hestad, Knut; Neupane, Sudan Prasad (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      <p><i>Background</i>: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment.</p> <p><i>Methods</i>: ...